Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers
نویسندگان
چکیده
منابع مشابه
Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers.
To better assess biomonitoring data in workers exposed to captan and folpet, the kinetics of ring metabolites [tetrahydrophthalimide (THPI), phthalimide (PI) and phthalic acid] were determined in urine and plasma of dermally exposed volunteers. A 10 mg kg(-1) dose of each fungicide was applied on 80 cm(2) of the forearm and left without occlusion or washing for 24 h. Blood samples were withd...
متن کاملToxicokinetics of permethrin biomarkers of exposure in orally exposed volunteers.
Permethrin is a widely used pyrethroid insecticide for which the toxicokinetics of exposure biomarkers in humans is not fully documented. The time courses of key biomarkers of permethrin exposure were thus assessed in accessible biological matrices of orally exposed volunteers. Six volunteers ingested 0.1 mg/kg body weight of permethrin (60:40 trans/cis). Blood samples were withdrawn at fixed p...
متن کاملSpectrophotometric determination of the fungicides captan and folpet in their commercial formulations
Captan and folpet react with thiophenol in the presence of triethylamine in acetonitrile to form a bis (phenyl) trithiocarbonate which reacts with 2, 4dinitrophenyl hydrazine in the presence of hydrochloric acid to form corresponding hydrazone. The latter is transformed into an intense red quinoidal ion immediately on making solution alkaline. This observation have been made the basis of a simp...
متن کاملEffect of age on toxicokinetics among human volunteers exposed to propylene glycol methyl ether (PGME).
UNLABELLED Aging adults represent the fastest growing population segment in many countries. Physiological and metabolic changes in the aging process may alter how aging adults biologically respond to pollutants. In a controlled human toxicokinetic study (exposure chamber; 12 m³), aging volunteers (n=10; >58 years) were exposed to propylene glycol monomethyl ether (PGME, CAS no. 107-98-2) at 50 ...
متن کاملFenitrothion: toxicokinetics and toxicologic evaluation in human volunteers.
An unblinded crossover study of fenitrothion 0.18 mg/kg/day [36 times the acceptable daily intake (ADI)] and 0.36 mg/kg/day (72 X ADI) administered as two daily divided doses for 4 days in 12 human volunteers was designed and undertaken after results from a pilot study. On days 1 and 4, blood and urine samples were collected for analysis of fenitrothion and its major metabolites, as well as pla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Applied Toxicology
سال: 2011
ISSN: 0260-437X
DOI: 10.1002/jat.1659